【摘要】 目的：探討腹腔鏡膽囊切除術(shù)對膽囊結(jié)石患者血清C反應(yīng)蛋白（CRP）和白細胞介素6（IL-6）水平的影響分析。方法：回顧性分析2014年4月-2016年4月于本院收治膽囊結(jié)石患者100例，根據(jù)手術(shù)方式不同將其分為腹腔鏡組及開腹組，各50例。開腹組給予常規(guī)開腹膽囊切除術(shù)治療，腹腔鏡組給予腹腔鏡膽囊切除術(shù)治療，統(tǒng)計分析兩組患者治療前后血清CRP、IL-6水平變化、免疫球蛋白變化及治療效果情況。結(jié)果：腹腔鏡組患者手術(shù)時間、術(shù)中出血量、肛門排氣時間及住院時間均少于開腹組，差異均有統(tǒng)計學意義（P<0.05）；腹腔鏡組患者治療后血清CRP、IL-6水平均低于開腹組，差異均有統(tǒng)計學意義（P<0.05）；腹腔鏡組患者治療后血清免疫球蛋白A、免疫球蛋白G、免疫球蛋白M（IgA、IgG、IgM）水平均高于開腹組，差異均有統(tǒng)計學意義（P<0.05）。結(jié)論：腹腔鏡膽囊切除術(shù)對膽囊結(jié)石患者有顯著臨床效果，對患者機體炎癥反應(yīng)、細胞免疫功能幾乎無影響，更有利于患者術(shù)后康復(fù)，值得臨床應(yīng)用。
　　【關(guān)鍵詞】 腹腔鏡膽囊切除術(shù)； 膽囊結(jié)石； CRP； IL-6
　　Effect Analysis of Laparoscopic Cholecystectomy on Serum CRP and IL-6 Levels of Patients with Gallbladder Stone/LI Pinggao.//Medical Innovation of China，2018，15（07）：056-059
　　【Abstract】 Objective：To discuss the effect analysis of laparoscopic cholecystectomy on serum CRP and IL-6 levels of patients with gallbladder stone. Method：100 patients with gallbladder stone were retrospectively analyzed from April 2014 to April 2016 in our hospital.According to different operation methods，all patients were divided into the experimental group（50 cases） and the control group（50 cases）， the control group was given conventional laparotomy cholecystectomy treatment，the experimental group was given laparoscopic cholecystectomy treatment.The changes of serum CRP and IL-6 levels，immune globulin，treatment effect of two groups were analyzed.Result：The operation time，intraoperative blood loss，anal exhaust time and hospital stay of the experimental group were significantly lower than those of the control groupthe differences were statistically significant（P<0.05）.After treatment，the serum levels of CRP，IL-6 of the experimental group were significantly lower than those of the control group，the differences were statistically significant（P<0.05）.The levels of IgA，IgG，IgM in the experimental group were significantly higher than those of the control group，the differences were statistically significant （P<0.05）.Conclusion：Laparoscopic cholecystectomy in patients with gallbladder stone has significant clinical effect，does not affect inflammation，cell immune function，it is more beneficial to postoperative rehabilitation，it’s worth for further clinical promotion.
　　【Key words】 Laparoscopic cholecystectomy； Gallbladder stone； CRP； IL-6
　　First-author’s address：Shantou Chaonan Minsheng Hospital，Shantou 515144 ，China
　　doi：10.3969/j.issn.1674-4985.2018.07.016
　　膽囊結(jié)石是普通外科常見疾病之一，我國成年人發(fā)病率約10%[1-2]，主要表現(xiàn)為惡食油膩、右腹部及左肩部疼痛，臨床上一般采用保守內(nèi)科治療和外科手術(shù)治療兩種方式，結(jié)石較小的患者可選擇保守治療，結(jié)石較大而保守治療無效或有阻塞則需要外科手術(shù)治療，傳統(tǒng)的開腹膽囊切除創(chuàng)傷較大、恢復(fù)慢及并發(fā)癥多，腹腔鏡膽囊切除切口小，但術(shù)中人工氣腹也可能造成機體有一定的損傷[3-4]。本研究通過對比腹腔鏡膽囊切除術(shù)與開腹膽囊切除術(shù)對膽囊結(jié)石患者術(shù)后的機體炎癥反應(yīng)及免疫功能的變化情況，而得知兩者對機體炎癥反應(yīng)及免疫功能的影響，現(xiàn)報道如下。

相關(guān)熱詞搜索：膽囊 血清 切除術(shù) 患者 腹腔鏡