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喹硫平與利培酮治療癡呆患者行為與精神障礙的對照研究

發(fā)布時間:2018-06-24 來源: 感悟愛情 點擊:


  [摘要] 目的 研究喹硫平與利培酮治療癡呆患者行為與精神障礙的效果。方法 方便選取該院2013年2月—2016年6月間診療的130例癡呆行為與精神障礙患者,按照盲選的形式,將65例患者施以喹硫平治療,設(shè)為A組;剩余65例施以利培酮治療,設(shè)為B組,比較2組患者治療療效、不良反應(yīng)、BEHAVE-AD評分、MMSE評分。結(jié)果 A組患者治療總有效率為96.92%,B組患者治療有效率為93.85%;A組患者不良反應(yīng)為4.61%,B組患者不良反應(yīng)為21.54%;A組患者BEHAVE-AD評分為(10.18±4.87)分、MMSE評分為(7.56±2.86)分;B組患者BEHAVE-AD評分為(16.89±5.13)分、MMSE評分為(11.71±3.23)分,即2組患者各數(shù)據(jù)比較,差異有統(tǒng)計學(xué)意義(P<0.05)。結(jié)論 喹硫平與利培酮治療療效相似,但喹硫平不良反應(yīng)相對較低,更適于癡呆行為與精神障礙患者,故值得推廣。
  [關(guān)鍵詞] 喹硫平;利培酮;癡呆;行為障礙;精神障礙
  [中圖分類號] R4 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-0742(2018)01(c)-0124-03
  [Abstract] Objective This paper tries to study the effects of quetiapine and risperidone in the treatment of dementia and mental disorders. Methods Statistical analysis of 130 cases of patients with dementia behavior and mental disorder in the hospital during February 2013 to June 2016 was conducted, in accordance with the blind form, 65 patients were treated with quetiapine as group A; the remaining 65 patients were treated with risperidone as group B, compared two groups of patients with curative effect, adverse reaction, BEHAVE-AD score, MMSE score. Results The total effective rate was 96.92% in group A and 93.85% in group B. The adverse reaction was 4.61% in group A and 21.54% in group B. The BEHAVE-AD score in group A was(10.18±4.87)points, and the MMSE score was(7.56±2.86)points. The BEHAVE-AD score of group B was(16.89±5.13)points and the MMSE score was (11.71±3.23)points. There was significant statistical difference between the two groups (P<0.05). Conclusion Quetiapine and risperidone treatment are of similar efficacy, but quetiapine adverse reactions are relatively lower, more suitable for dementia behavior and mental disorders, it is worth promoting.
  [Key words] Quetiapine; Risperidone; Dementia; Behavioral disorders; Mental disorders
  人口老齡化的逐漸加快,促使阿爾茨海默病、腦血管病病發(fā)率顯著攀升,而在癡呆患者進(jìn)入某病程進(jìn)展時,則80%~90%均會不同程度的行為和精神障礙,經(jīng)世界老年精神病學(xué)會(1996年)將該病統(tǒng)稱為“癡呆伴發(fā)的行為和精神癥狀(BPSD)”[1-2]。目前,喹硫平、利培酮均屬于非典型抗精神病類藥,尤其對老年癡呆患者的藥效作用[3]。故該研究統(tǒng)計分析2013年2月—2016年6月間診療的130例癡呆行為與精神障礙患者,研究喹硫平與利培酮治療癡呆患者行為與精神障礙的效果。
  1 資料與方法
  1.1 一般資料
  方便選取該院診療的130例癡呆行為與精神障礙患者,按照盲選的形式,將65例患者施以喹硫平治療,設(shè)為A組;剩余65例施以利培酮治療,設(shè)為B組。A組:男性32例、女性33例;年齡區(qū)間在60~85歲,年齡中位數(shù)為(72.5±12.5)歲;病程區(qū)間在6~23個月,病程中位數(shù)為(14.5±8.5)個月。B組:男性35例、女性31例;年齡區(qū)間在62~87歲,年齡中位數(shù)為(74.5±12.5)歲;病程區(qū)間在8~21個月,病程中位數(shù)為(14.5±6.5)個月。2組患者基線資料比較,差異無統(tǒng)計學(xué)意義(P>0.05)。130例患者中,阿爾茨海默病78例、血管性癡呆52例。
  1.2 方法
  A組:富馬酸喹硫平(國藥準(zhǔn)字H20000466),初始劑量為25 mg/d,早晚各1次;以1~3 d為時間間隔,將口服劑量逐次增加25 mg[4],即將藥物劑量增加至200~500 mg/d,可早晚各1次。B組:利培酮(國藥準(zhǔn)字H20041808),初始劑量為0.5 mg,2次/d;第3天增加至日劑量2 mg;1周內(nèi)劑量提升至4~5 mg;此后該劑量保持穩(wěn)定,但據(jù)情況可依據(jù)患者病情予以酌情調(diào)整[5]。

相關(guān)熱詞搜索:對照 癡呆 精神障礙 患者 治療

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