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胰島素強(qiáng)化基礎(chǔ)餐時劑量調(diào)整時間療效對照研究

發(fā)布時間:2018-06-24 來源: 人生感悟 點(diǎn)擊:


  [摘要] 目的 對照研究胰島素強(qiáng)化基礎(chǔ)餐時劑量調(diào)整時間對臨床療效的影響。 方法 選擇2016年5月—2017年5月期間在該院行胰島素強(qiáng)化治療的190例2型糖尿病患者,隨機(jī)分為對照組和觀察組。兩組均采用胰島素強(qiáng)化基礎(chǔ)餐時方案治療,觀察組執(zhí)行臨時醫(yī)囑(每餐調(diào)整劑量),對照組執(zhí)行長期醫(yī)囑(2~3 d調(diào)整1次),觀察兩組患者治療后血糖指標(biāo)變化及不良反應(yīng)情況。 結(jié)果 治療1周后、2周后,觀察組空腹和餐后2 h血糖指標(biāo)均顯著低于對照組,組間差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。觀察組低血糖反應(yīng)發(fā)生率(8.42%,8/95)顯著低于對照組(17.89%,17/95),組間差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。 結(jié)論 胰島素強(qiáng)化基礎(chǔ)餐時方案臨時醫(yī)囑療效優(yōu)于長期醫(yī)囑,可有效提升血糖控制效果,降低低血糖發(fā)生率。
  [關(guān)鍵詞] 胰島素強(qiáng)化餐時基礎(chǔ)方案;臨時醫(yī)囑;長期醫(yī)囑;對照研究
  [中圖分類號] R587.1 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1672-4062(2017)11(b)-0062-02
  [Abstract] Objective To compare and research the curative effect of insulin intensive basal-bolus dosage adjustment time. Methods 190 cases of type 2 diabetes patients for insulin intensive therapy in our hospital from May 2016 to May 2017 were selected and randomly divided into two groups, both groups used the insulin intensive basal-bolus therapy, while the observation group conducted the temporary doctor’s signs (adjusting dosage each dinner), while the control group conducted the long-term doctors’ signs (adjusting the dosage every two to three days), and the changes of blood glucose and adverse reactions after treatment of the two groups were observed. Results After 1 week and 2 weeks, the fasting and postprandial 2 h blood glucose indicators in the observation group were obviously lower than those in the control group, and the differences were obvious(P<0.05), and the incidence rate of hypoglycemia reactions in the observation group was obviously lower than that in the control group[(8.42%, 8/95) vs (17.89%, 17/95)], and the differences between groups were obvious(P<0.05). Conclusion The curative effect of temporary doctors’ signs of insulin intensive basal-bolus plan is better than that of long-term doctors’ signs, which can effectively improve the blood glucose control effect and reduce the incidence rate of hypoglycemia.
  [Key words] Insulin intensive basal-bolus plan; Temporary doctors’ signs; Long-term doctors’ signs; Research on comparison
  胰島素強(qiáng)化治療是一種強(qiáng)化血糖控制的胰島素治療模式,在飲食控制和運(yùn)動療法的基礎(chǔ)上,通過每日多次(3~4次)皮下注射胰島素,達(dá)到相對理想的血糖控制水平[1]。當(dāng)前,胰島素強(qiáng)化治療在糖尿病治療中應(yīng)用廣泛,用藥方案也存在較多選擇,其中胰島素強(qiáng)化基礎(chǔ)餐時方案臨床應(yīng)用較多,但是在其治療時劑量調(diào)整時間方面尚存在爭議。為此,該次研究選擇2016年5月—2017年5月期間在該院行胰島素強(qiáng)化治療的190例2型糖尿病患者,對照研究了胰島素強(qiáng)化基礎(chǔ)餐時不同劑量調(diào)整時間的臨床療效,現(xiàn)報(bào)道如下。
  1 資料與方法
  1.1 一般資料
  選擇間在該院行胰島素強(qiáng)化治療的190例2型糖尿病患者,隨機(jī)分為對照組和觀察組,各95例。兩組患者均符合美國糖尿病學(xué)會(ADA)關(guān)于2型糖尿病診斷標(biāo)準(zhǔn)[2]。排除標(biāo)準(zhǔn)[3]:排除Ⅰ型糖尿病、心腦血管并發(fā)癥、肝腎功能不全、頻繁低血糖者、妊娠期及哺乳患者。觀察組,男48例,女47例,年齡40~65歲,平均(52.43±12.57)歲,病程1~14年,平均(7.49±6.35)年。對照組,男49例,女46例,年齡40~65歲,平均(52.52±12.42)歲,病程1~13年,平均(7.16±6.05)年。兩組患者在病程、既往病史等一般資料方面,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),具有可比性。

相關(guān)熱詞搜索:胰島素 劑量 對照 療效 強(qiáng)化

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