[摘要] 目的 探討宮頸上皮細(xì)胞穩(wěn)定性游離亞鐵原卟啉（FH）檢測在不同年齡段宮頸癌診斷中的意義。 方法 回顧性分析湖南省腦科醫(yī)院2014年10月～2017年10月收治的213例宮頸腫瘤患者的臨床資料，將其按年齡分為≤30歲、>30～40歲、>40～50歲、>50～60歲、>60～70歲及>70歲6個年齡段，均行手術(shù)治療且均經(jīng)病理檢測明確診斷，另均行上皮細(xì)胞穩(wěn)定性FH檢測。對比不同年齡段FH檢測結(jié)果，分析不同年齡段FH檢測的靈敏度、特異度及準(zhǔn)確度，并繪制基于上皮穩(wěn)定性FH的檢測結(jié)果在不同年齡段宮頸腫瘤患者中的工作曲線（ROC），得出曲線下面積（AUC）。 結(jié)果 >40～50歲者與>60～70歲者的總陽性率均明顯高于≤30歲、>30～40歲、>50～60歲及>70歲者（P < 0.05），但其他各年齡段兩兩比較差異無統(tǒng)計學(xué)意義（P > 0.05）；宮頸上皮細(xì)胞穩(wěn)定性FH染色檢測≤30歲、>30～40歲、>40～50歲、>50～60歲、>60～70歲及>70歲宮頸癌患者分別有10、25、56、9、50例及11例，而病理學(xué)診斷則分別有7、21、55、7、49例及8例；不同年齡段宮頸腫瘤患者進行上皮細(xì)胞穩(wěn)定性FH檢測均具有較高的靈敏度、特異度及準(zhǔn)確度，但>40～50歲與>60～70歲者高于其他年齡段；上皮細(xì)胞穩(wěn)定性FH檢測>40～50歲、>60～70歲、>30～40歲、>70歲、>50～60歲及≤30歲的AUC分別為0.956、0.949、0.819、0.763、0.727及0.725。 結(jié)論 宮頸上皮細(xì)胞穩(wěn)定性FH檢測在不同年齡段宮頸癌診斷中均具有一定的可靠性，但在>40～50歲與>60～70歲者中靈敏度、特異度及準(zhǔn)確度相對較高，可用于指導(dǎo)臨床宮頸癌篩查及診斷。
　　[關(guān)鍵詞] 宮頸上皮細(xì)胞穩(wěn)定性游離亞鐵原卟啉；宮頸癌；年齡段
　　[中圖分類號] R737.33 [文獻標(biāo)識碼] A [文章編號] 1673-7210（2018）02（c）-0110-05
　　Significance of detection of cervical epithelial cell stability free ferrous protoporphyrin in the diagnosis of cervical cancer in different ages
　　ZHAO Ying ZHOU Xunhua CHEN Yanhui
　　Department of Gynecology and Obstetrics， Hu"nan Brain Hospital， Hu"nan Province， Changsha 410007， China
　　[Abstract] Objective To investigate the significance of detection of cervical epithelial cell stability free ferrous protoporphyrin （FH） in the diagnosis of cervical cancer in different ages. Methods The clinical data of 213 cases of patients with cervical tumor admitted to Hu"nan Brain Hospital from October 2014 to October 2017 was retrospectively analyzed. They were divided into 6 age groups of ≤30 years old， >30-40 years old， >40-50 years old， >50-60 years old， >60-70 years old， and >70 years old by age， and all the patients were treated with surgical treatment and diagnosed by pathological examination， also they were detected by cervical epithelial cells stability FH. The results of FH detection at different ages were compared， and the sensitivity， specificity and accuracy of FH test in different age groups were analyzed， then the receiver operating curves （ROC） of patients with high-risk cervical cancer in different age groups based on uterine epithelial cells stability FH were made， and the area under curves （AUC） were obtained. Results The total positive rates of people at age of >40-50 years old and >60-70 years old were significantly higher than those of ≤30 years old， >30-40 years old， >50-60 years old and >70 years old （P < 0.05）， but there were no significant differences between the other age groups （P > 0.05）. There were respectively 10， 25， 56， 9， 50 cases and 11 cases of ≤30 years old， >30-40 years old， >40-50 years old， >50-60 years old， >60-70 years old and >70 years old by cervical epithelial cells stability FH， while there were respectively 7， 21， 55， 7， 49 cases and 8 cases of ≤30 years old， >30-40 years old， >40-50 years old， >50-60 years old， >60-70 years old and >70 years old by immunocytochemistry examination. Epithelial cells stability FH detection had higher sensitivity， specificity and accuracy in different age groups， which of >40-50 years old and >60-70 years old were higher than other age groups. The AUC of the uterine epithelial cells stability FH for the detection of people at age of >40-50 years old， >60-70 years old， >30-40 years old， >70 years old， >50-60 years old， and ≤30 years old were 0.956， 0.949， 0.819， 0.763， 0.727 and 0.727 respectively. Conclusion Cervical epithelial cells stability FH staining are reliable in the diagnosis of cervical cancer at different ages， but the sensitivity， specificity and accuracy of >40-50 years old and >60-70 years old are relatively higher other ages， which can be used to guide clinical screening and diagnosis of cervical cancer.

相關(guān)熱詞搜索：亞鐵 卟啉 宮頸癌 宮頸 年齡段