[摘要]目的 評價米索前列醇不同的給藥途徑治療稽留流產的臨床效果。方法 選取莆田學院附屬醫(yī)院2015年1月～2016年6月收治的80例稽留流產患者作為研究對象，隨機分為試驗組和對照組，每組各40例。試驗組給予米非司酮150 mg口服聯合米索前列醇片0.6 mg塞陰，對照組給予米非司酮150 mg口服聯合米索前列醇片0.6 mg口服。觀察比較兩組患者的子宮收縮時間、服藥后排胚時間、排胚后2 h出血量及完全流產率。結果 試驗組患者的子宮收縮時間及排胚時間明顯早于對照組，差異有統計學意義（P<0.05）；試驗組排胚后2 h出血量明顯少于對照組，差異有統計學意義（P<0.05）。試驗組完全流產率為20.0%，高于對照組的5.0%，差異有統計學意義（P<0.05）。結論 米非司酮聯合米索前列醇塞陰治療稽留流產的臨床效果明顯優(yōu)于米非司酮聯合米索前列醇口服，排胚后清宮率較低。
　　[關健詞]米非司酮；米索前列醇；給藥途徑；臨床療效
　　[中圖分類號] R378.5 [文獻標識碼] A [文章編號] 1674-4721（2018）2（b）-0053-03
　　Analysis on the clinical effect of different routes of medication in the treatment of missed abortion
　　HUANG Jian-xiong LI Li-jun CHI Hui-juan
　　Department of Obstetrics and Gynecology，Affiliated Hospital of Putian College，Fujian Province，Putian 351100，China
　　[Abstract]Objective Evaluation of clinical effect of Misoprostol on different routes of medication in the treatment of missed abortion.Methods 80 cases of patients with missed abortion from putian college affiliated hospital from January 2015 to June 2016 were selected as the subjects，and randomly divided into the experimental group and the control group，40 cases in each group.The test group received 150 mg oral Mifepristone combined with Misoprostol 0.6 mg plug vagina.The control group received 150 mg oral Mifepristone combined with Misoprostol 0.6 mg oral.The uterine contraction time，time of discharge of embryo after taking medicine，the amount of bleeding and the rate of complete abortion after 2 hours between the two groups were observed and compared.Results In the experimental group，the time of uterine contraction and the discharge time were significantly less than those in the control group，the difference was statistically significant （P<0.05）.The amount of bleeding in the experimental group was significiantly less than that in the control group after 2 h，the difference was statistically significant （P<0.05）.The complete abortion rate was 20.0% in the test group，higher than 5.0% in the control group，the difference was statistically significant （P<0.05）.Conclusion Mifepristone combined Misoprostol plug vagina for missed abortion has better clinical efficacy than Mifepristone combined Misoprostol oral，which has the lower rate of embryos after discharge.
　　[Key words]Mifepristone；Misoprostol；Routes of medication；Clinical effect
　　稽留流產，是自然流產的一種特殊類型，指胚胎或胎兒已死亡滯留宮腔內未能及時自然排出。研究發(fā)現，稽留流產的發(fā)病率逐年上升，占所有自然流產的42.21%，而發(fā)生在妊娠8周以前占80%[1]。處理稽留流產的方法有藥物治療和刮宮治療。由于大部分患者有生育要求且擔心刮宮術的副作用，所以更適合藥物治療。米非司酮聯合米索前列醇應用于稽留流產的藥物治療效果確切，但由于其排胚后出血時間長及排胚后完全流產率低等不足，限制了其應用范圍。本研究旨在探討米索前列醇的不同給藥方式聯合米非司酮治療稽留流產的臨床效果，現報道如下。

相關熱詞搜索：稽留 流產 臨床 給藥 途徑