生長(zhǎng)抑素與奧曲肽在肝硬化上消化道出血治療中的應(yīng)用對(duì)比研究
發(fā)布時(shí)間:2018-06-23 來源: 散文精選 點(diǎn)擊:
[摘要] 目的 對(duì)比生長(zhǎng)抑素和奧曲肽對(duì)肝硬化上消化道出血的治療效果。 方法 將86例肝硬化上消化道出血患者視為研究對(duì)象,根據(jù)治療方法的不同將患者分為對(duì)照組(n=43)和研究組(n=43),對(duì)照組應(yīng)用奧曲肽,研究組采用生長(zhǎng)抑素,將兩組的臨床療效進(jìn)行對(duì)比。 結(jié)果 研究組的總有效率(95.35%)高于對(duì)照組(81.40%),差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。研究組的不良反應(yīng)發(fā)生率(6.98%)低于對(duì)照組(23.26%),差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。研究組止血所用時(shí)間短于對(duì)照組,且研究組的輸血量少于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P<0.05)。 結(jié)論 在肝硬化上消化道出血患者的治療中,生長(zhǎng)抑素對(duì)患者病情的緩解作用較好,止血速度較快,輸血量少,且不良反應(yīng)較少,應(yīng)用價(jià)值較高。
[關(guān)鍵詞] 奧曲肽;生長(zhǎng)抑素;肝硬化;上消化道出血
[中圖分類號(hào)] R575.2;R573.2 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701(2018)08-0040-02
Comparative analysis of somatostatin and octreotide on upper gastrointestinal bleeding in patients with cirrhosis
ZHANG Xiaoqing
Jiamusi Infectious Disease Hospital in Heilongjiang Province, Jiamusi 154007, China
[Abstract] Objective To investigate the clinical effectiveness of somatostatin and octreotide on upper gastrointestinal bleeding (UGB) in patients with cirrhosis. Methods A total of 86 patients with cirrhosis and UGB were divided into control group(n=43) and study group(n=43) according to their treatment. Patients in control group were treated with octreotide while patients in study group with somatostatin. Clinical effectiveness was analyzed in two groups. Results The overall rate of effectiveness in study group (95.53%) was higher than that in control group (81.40%) (P<0.05). The incidence of adverse reaction in study group (6.98%) was smaller than that in control group (23.26%) (P<0.05). Time used for hemostasis in study group was shorter than control group and the amount of blood transfusion in study group was less than control group(P<0.05). Conclusion In the treatment of UGB in patients with cirrhosis, somatostatin was of application value and beneficial for patients" disease with faster hemostasis, less amount of blood transfusion and less complications.
[Key words] Octreotide; Somatostatin; Cirrhosis; Upper Gastrointestinal Bleeding
肝硬化晚期的常見并發(fā)癥之一是上消化道出血,肝硬化后,患者的門靜脈氣壓明顯增高,導(dǎo)致靜脈曲張,因壓力過大食管胃底靜脈破裂出血,病情發(fā)展速度快,出血量較大[1-2];颊叱霈F(xiàn)嘔血癥狀、面色蒼白、心慌、排黑便、出冷汗等,可導(dǎo)致患者發(fā)生失血性休克、窒息等并發(fā)癥,嚴(yán)重威脅患者的生命安全[3-4]。因此,發(fā)病后,患者應(yīng)及時(shí)到醫(yī)院就醫(yī),以及時(shí)控制病情的發(fā)展,減少患者的出血量,促進(jìn)患者康復(fù)。奧曲肽是臨床對(duì)肝硬化上消化道出血患者經(jīng)常采用的治療藥物,此外,生長(zhǎng)抑素也常被用于該疾病患者的治療中,但不同的藥物其治療效果有所差異[5]。為探討此兩種藥物對(duì)肝硬化上消化道出血患者的效果,本研究將我院接手和診治的86例患者分為兩組,分別給予生長(zhǎng)抑素、奧曲肽進(jìn)行止血治療,并就兩種藥物的治療效果進(jìn)行比較和分析,現(xiàn)報(bào)道如下。
1 資料與方法
1.1一般資料
本研究的觀察對(duì)象為肝硬化上消化道出血患者86例,所選對(duì)象均于2016年3月~2017年4月在我院接受治療;颊叩呐R床癥狀均符合診斷標(biāo)準(zhǔn);本研究將妊娠或哺乳期患者、嚴(yán)重肝腎心功能不全患者、惡性腫瘤患者、對(duì)本研究藥物過敏者、嚴(yán)重血液疾病者排除在外[6]。根據(jù)治療時(shí)間的先后順序以及治療方法的不同將所有患者分為研究組、對(duì)照組,每組43例。研究組男女比例為23∶20;年齡24~66歲,平均(32.35±3.41)歲;肝硬化病程2~6年,平均(3.25±1.06)年。對(duì)照組男女比例為22:21;肝硬化病程1~6年,平均(3.17±1.02)年;年齡25~65歲,平均(32.41±3.23)歲。兩組患者的基本資料比較,差異無統(tǒng)計(jì)學(xué)意義(P>0.05),可展開對(duì)比研究。
相關(guān)熱詞搜索:肝硬化 消化道 出血 生長(zhǎng) 治療
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