宮頸癌擴(kuò)散峰度成像檢查的可重現(xiàn)性研究
發(fā)布時(shí)間:2018-06-23 來源: 散文精選 點(diǎn)擊:
[摘要]目的 評(píng)估磁共振擴(kuò)散峰度成像(DKI)應(yīng)用于宮頸癌檢查的可重現(xiàn)性。方法 選取我院2016年6~12月的10例宮頸癌患者和10名健康志愿者,于相隔24 h~14 d進(jìn)行2次軸位DKI掃描,測(cè)量峰度參數(shù)K以及擴(kuò)散參數(shù)D,并用SPSS 19.0軟件進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果 總受試者、志愿者和宮頸癌患者參數(shù)D的組內(nèi)變異系數(shù)(ICC)分別為0.899、0.935和0.828,參數(shù)K的ICC分別為0.870、0.871和0.877?偸茉囌、志愿者和宮頸癌患者參數(shù)D的變異系數(shù)分別為17.23%、16.43%和16.51%,參數(shù)K的變異系數(shù)分別為17.85%、20.16%和12.28%。結(jié)論 DKI序列在檢測(cè)宮頸組織水分子非高斯擴(kuò)散方面具有較好的可重現(xiàn)性。
[關(guān)鍵詞]擴(kuò)散峰度成像;磁共振;宮頸癌;可重現(xiàn)性
[中圖分類號(hào)] R737.33 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721(2018)2(b)-0011-04
Reproducibility of diffusional kurtosis imaging measurement in uterine cervical carcinoma
ZHENG Xiang1 CHEN Yun-bin1 CHEN Wen-juan2 CHEN Wei-bo3
1.Department of Radiologic Diagnosis,F(xiàn)ujian Cancer Hospital,F(xiàn)uzhou 350014,China;2.Department of Gynecological Oncology,F(xiàn)ujian Cancer Hospital,F(xiàn)uzhou 350014,China;3.PHILIPS Healthcare,Shanghai 200333,China
[Abstract]Objective To evaluate the reproducibility of magnetic resonance imaging (MRI) diffusional kurtosis imaging (DKI) in detecting of cervical carcinoma.Methods 10 patients and 10 healthy volunteers in our hospital from June to December in 2016 were selected and underwent duplicate MRI scans by using DKI with an interval of 24 hours to 14 days.The metric K and D were obtained from parametric maps and evaluated by statistical software SPSS 19.0.Results The D value of intra group variation coefficient (ICC) of the total subjects,volunteers, and cervical cancer patients were 0.899,0.935 and 0.828,respectively.The ICC of parameter K was 0.870,0.871 and 0.877,respectively.The coefficients of variation of the D in the total subjects,the volunteers and the patients with cervical cancer were 17.23%,16.43% and 16.51%,respectively.The coefficients of variation of parameter K were 17.85%,20.16% and 12.28%,respectively.Conclusion DK imaging sequence appears reproducible in detecting the non Gauss diffusion of water molecules in cervical carcinoma.
[Key words]Diffusional kurtosis imaging;Magnetic resonance imaging;Cervical carcinoma;Reproducibility
宮頸癌是我國女性常見的惡性腫瘤,其診斷以及療效評(píng)判多依賴于核磁共振成像(MRI)。MRI可提供病灶在治療前后形態(tài)學(xué)上的變化過程,但是對(duì)于早期微小病灶,常規(guī)MRI并不能有效發(fā)現(xiàn)。有學(xué)者發(fā)現(xiàn)腫瘤放療后其功能學(xué)變化早于形態(tài)學(xué)[1]。作為功能磁共振的一個(gè)序列,擴(kuò)散加權(quán)成像DWI參數(shù)表觀擴(kuò)散系數(shù)(ADC)可用檢測(cè)腫瘤早于形態(tài)學(xué)變化之前的功能學(xué)變化,以此評(píng)估治療效果[2]。然而作為一個(gè)以假設(shè)水分子遵循高斯分布為前提的序列,DWI并不能完全能準(zhǔn)確描述水分子在人體內(nèi)的擴(kuò)散狀況。
擴(kuò)散峰度成像(DKI)也是擴(kuò)散功能成像系列的一員,2005年首次被提及[3],主要用于描述非高斯分布的水分子擴(kuò)散。由于非高斯分布更符合水分子在人體內(nèi)的實(shí)際擴(kuò)散方式,因此DKI可提供更為精確的信息。目前DKI的研究主要集中于中樞神經(jīng)系統(tǒng),包括腦梗死、膠質(zhì)瘤、多發(fā)性硬化、帕金森病、注意力集中缺陷等[4-8]。此外還有一些中樞神經(jīng)系統(tǒng)外的疾病,如支氣管畸形、肝細(xì)胞癌和前列腺癌[9-12]。但是關(guān)于DKI在宮頸癌中的應(yīng)用,目前尚未見文獻(xiàn)報(bào)道,因此本研究擬評(píng)估DKI序列應(yīng)用于宮頸癌的可重現(xiàn)性,以便臨床診斷宮頸癌以及進(jìn)一步評(píng)估宮頸癌療效提供理論基礎(chǔ)。
相關(guān)熱詞搜索:宮頸癌 成像 擴(kuò)散 重現(xiàn) 檢查
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